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Napo Pharmaceuticals Secures $2 Million in Financing

Napo Pharmaceuticals, Inc. (“Napo”), announced today that it has obtained $2 million in secured convertible debt financing from New York-based Kingdon Capital Management, LLC. Proceeds from the financing will primarily be used by Napo for the commercialization of Mytesi.

Mytesi (crofelemer) is the only antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Napo introduced Mytesi in the U.S. this past October.

“We’re pleased to have additional funds to build inventory and achieve greater awareness of Mytesi among people living with HIV/AIDS,” commented Katie MacFarlane, Senior Vice President of Commercial Development at Napo. “Surveys indicate that 1 in 5 people living with HIV experience diarrhea, and there is a growing demographic of those who have lived with HIV for more than a decade—a population that may be more at risk for experiencing diarrhea.”

As previously announced, Napo has signed a non-binding letter of intent (“LOI”) with Jaguar Animal Health, Inc. (NASDAQ: JAGX) (“Jaguar”) potentially to merge the two companies. Napo has provided Jaguar with exclusive worldwide rights for veterinary applications to crofelemer and corresponding rights to all related Napo technology.

About Mytesi™
Mytesi (crofelemer) is an antidiarrheal indicated for the symptomatic relief of noninfectious diarrhea in adult patients with HIV/AIDS on antiretroviral therapy (ART). Mytesi is not indicated for the treatment of infectious diarrhea. Rule out infectious etiologies of diarrhea before starting Mytesi. If infectious etiologies are not considered, there is a risk that patients with infectious etiologies will not receive the appropriate therapy and their disease may worsen. In clinical studies, the most common adverse reactions occurring at a rate greater than placebo were upper respiratory tract infection (5.7%), bronchitis (3.9%), cough (3.5%), flatulence (3.1%), and increased bilirubin (3.1%).More information and complete Prescribing Information are available at Mytesi.com.

About Napo Pharmaceuticals, Inc.
San Francisco-based Napo Pharmaceuticals, Inc., focuses on the development and commercialization of proprietary pharmaceuticals from rainforest resources for the global marketplace in collaboration with local partners.

About Kingdon Capital Management, LLC
Kingdon Capital Management, LLC is a New York-based alternative investment firm founded by Mark Kingdon in 1983. The firm is a registered investment advisor regulated by the U.S. Securities and Exchange Commission and has approximately $2 billion of assets under management.

Media Contacts:
Kate Tumino
KCSA Strategic Communications
ktumino@kcsa.com
212-896-1252

How to Happily Make it Through the Holidays with HIV

By: Josh Robbins, Plus Magazine

When you live with HIV you’re unable to check the physical symptoms that come with it at the door with your coats at the party. People living with HIV need real solutions – ones that talk about how to get out of the house and live their lives. Here are some tips I’ve learned that have made them much more managable and less anxiety ridden.

Get Support from Your Doctor  Communicate with your doctor about your symptoms. For example, one of the most common symptoms that tend to stop patients living with HIV from enjoying the holidays is diarrhea. It may be uncomfortable to discuss, but there are treatment options that may be right for you.

Treatments for Diarrhea Exist  Ask your doctor about Mytesi (crofelemer), which is a prescription drug now available – the first and only antidiarrheal drug that was specifically studied in and FDA-approved for people living with HIV. You are not alone, 1 in 5 people living with HIV report experiencing diarrhea. Visit: EnoughDiarrhea.com to learn more.

Traveling a long distance?  If you have a prescription that needs to be refrigerated, wrap it in a cold pack in your luggage. If your medication needs to be taken with food, be sure to pack a snack. Also, check with your pharmacy in advance to make sure you have enough medication to get you through the holidays.

Stay Healthy  Try to organize the best you can to be ready for physical stress of the holiday parties. It is important to get enough sleep and exercise, eat healthy and take your meds on time. If you have a lot going on during the holiday season, set alerts/calendar reminders on when to take your meds! Since you will be surrounded by multiple people during the holidays, it is very important to always protect your immune system. Bring hand sanitizer with you and wash your hands frequently.

Keep Your Mind Right = Keeping Your Body Right  Sit down and look at the calendar for the upcoming holiday season. If there are events you know you want to attend, be sure to plan how to make it happen in advance so you won’t be stressed at the last minute!Don’t Overdo   Say no when you have reached your limit – physical, social and emotional.

Most Importantly: Trust Yourself  Listen to your own voice: Focus on enjoying the holidays in the perfect way that makes you happy, comfortable, and healthy. Ultimately remember, the holidays will end and life will return to a more normal routine.

Josh Robbins publishes I’m Still Josh! the popular HIV blog the runs that’s been featured on MTV, ABC News and The Huffington Post.

Source: www.hivplusmag.com/stigma/2016/12/27/how-happily-make-it-through-holidays-hiv

Got the Runs? There’s a New Drug For That!

By: David Artavia, Plus Magazine

It’s time we as a community start discussing the elephant in the room: diarrhea. We get it — no one wants to mention that it’s one of a few common side effects of having HIV. It’s embarrassing, somewhat degrading, and more often than not we think we’re the only person going through it. But we’re not.

There are 18 million people with HIV currently on antiretroviral therapies, and according to a study by Patrick Clay, presented at ID Week, one in five HIV-positive people experience diarrhea. Most of them self-medicate without their doctor’s knowldge by either restricting certain types of foods, making severe changes to their lifestyle habits, or worse, taking over-the-counter antidiarrheal drugs that cause constipation or have not been proven safe in people with HIV.

 The study shows neither doctors nor their patients have taken a real step towards fixing the problem. As a result, diarrhea is seriously underreported despite the fact that 66 percent of healthcare providers say it’s the most troublesome adverse effect of antiretroviral therapy.

And surprisingly, doctor reports seem to contradict that of patient reports, stating that only 19 percent of their HIV-positive patients experience diarrhea and seven percent were treated with antidiarrheals, while patients reports say that 21 percent of them experience diarrhea and 10 percent were taking antidiarrheals.

The good news is there is hope.

A new FDA-approved antidiarrheal drug is on the market that relieves diarrhea specifically in HIV-positive patients, without jeopardizing drug interactions or causing constipation.

This fall, Napo Pharmaceuticals released Mytesi in tandem with two patient assistant programs. Part of their advocacy program is to increase awareness of this miracle drug among those living with HIV, so that healthcare providers know there is a better option other than over-the-counter meds.

“Diarrhea can be embarrassing, and it is not a topic that people usually bring up on their own,” Napo Pharmaceuticals CEO and Founder Lisa Conte said in a statement. “People living with HIV typically don’t report diarrhea to their physician because they have been dealing with it for a long time and they don’t know their physician has anything new to offer them… We want to educate patients and their healthcare providers to let them know this product is available and hope to spark a conversation among those that are suffering from diarrhea.”

HIV specialist Dr. Roger D. MacArthur recommended that doctors be more forthright with their HIV-positive patients experiencing diarrhea, and need to check in with them at least every six months.

“For patients who may have been ‘suffering in silence’ for a long time,” MacArthur suggested, “doctors should change their question from ‘have there been any changes in your bowel habits’ to ‘are there any issues you are having with diarrhea or loose stools that you want to discuss?’ One of the greatest challenges is that there are many things that receive more focus in a normal office visit such as recent lab results and adherence to ART, so sometimes diarrhea is not discussed.”

Source: www.hivplusmag.com/research-breakthroughs/2016/12/22/most-hiv-people-have-diarrhea-now-there-hope

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